Agrotechnology Study Program, Faculty of Agriculture, Sebelas Maret University (UNS), held a guest lecture on implementing Program Kompetisi Kampus Merdeka (PKKM) grant. A guest lecture on Biotechnology held on Wednesday, August 18, 2021, at 08:00 WIB or 09:00 PM (United States Time), using the Zoom online method. The guest lecture on Biotechnology, Prof. Herry S. Utomo, M.S., Ph.D., lecturer at Louisiana State University, United States of America. He is a researcher of rice with high protein content and low glycemic index. The guest lecture began with remarks by Vice Chancellor for Academic Affairs UNS, Prof. Dr. Ir. Ahmad Yunus, M.S. and the Dean of the Faculty of Agriculture UNS, Prof. Dr. Ir. Samanhudi, S.P., M.Sc., IPM, ASEAN Eng. The guest lecture was guided by moderator Andriyana Setyawati, S.P., M.P., Ph.D. Also present was the Head of the UNS Agrotechnology Study Program, Dr. Ir. Parjanto, M.P., Chairperson in Charge of PKKM, Prof. Dr. Ir. Endang Yuniastuti, M.Sc., Head of Person in Charge Dr. Ir. Amalia Tetrani Sakya, M.P., M.Phil., also lecturers and students of the UNS Agrotechnology Study Program. Also present were participants from outside UNS, namely students and lecturers from Brawijaya University, Sorong, North Sumatra University and Palangkaraya. Prof. Herry S. Utomo, M.S., Ph.D., delivered “Biotechnological Approach to Controlling Diabetes and Obesity” presentation. The United States of America is ranked first globally with an obese population, while Indonesia is ranked 10th. Obesity is a trigger for various diseases, including diabetes. One solution to overcome this disease is to develop low glycemic index rice. Rice assembled by Prof. Herry S. Utomo and the team were named “Frontière”. Prof. Herry and his team started research on low glycemic index rice from the laboratory to marketing. The initial stages of developing low glycemic index rice are carried out by mutation, regeneration and mutant production, selection (Headrow selection and genetic testing, multi-site/year, Human Clinical Trials for the Glycemic Index), release and protection of varieties, issuance of licenses and royalties as well as the marketing of low glycemic index rice become commercial products. This low glycemic index rice product is in demand in the United States because the market share in the United States has a high interest in food products with gluten-free. This guest lecture was enthusiastically responded to by the participants, marked by many questions related to the technical provision of low glycemic rice through mutation and solutions for diabetes and obesity