Agrotechnology Study Program, Faculty of Agriculture, Universitas Sebelas Maret (UNS) held a guest lecture to achieve a world-class university. Guest lecture on the topic of General Introduction of Natural Products Chemistry on Tuesday, November 10, 2020, at 1.30 pm, with the ZOOM method. Prof. Tohru Mitsunaga is a lecturer at Gifu University, Japan. He is a researcher in the field of natural product chemistry, exploring the content of compounds contained in a plant and testing the activity of plant compounds in several biological activities in a cell. The guest lecture began with remarks from the dean of the Faculty of Agriculture, Prof. Dr. Ir. Samanhudi, S.P., M.Si, IPM. ASEAN Eng. The guest lecture was guided by moderator Andriyana Setywati, SP., MP., Ph.D. Also present the Head of Agrotechnology Study Program, Dr. Ir. Parjanto, M.P. as well as lecturers and students of the UNS Agrotechnology Study Program. The Keynote speaker, Prof. Tohru Mitsunaga delivered material on the effectiveness of several native Indonesian plants that have activity in reducing melanin content (whitening agent) such as Red Ginger (Z. Officinale), and Bangle (C. Purpureum), Jajalakan (Helminthostachys zeylanica). He also conducted research related to Autonomic nerve stimulants (Depression, Obesity), several plants that have effectiveness in controlling Autonomic nerve stimulants are Cypress (Cgraucopjylla), and Hinoki (C.obtusa). This guest lecture was enthusiastically responded to by the guest lecture participants who were marked by many questions related to the effectiveness of several plants against melanin and several compounds related to autonomic nerve stimulants.