The Agrotechnology Study Program, Faculty of Agriculture, Universitas Sebelas Maret (UNS) held a guest lecture to achieve a world-class university. Guest lecture with the topic of Bioactivity ingredients from medicinal plants, on Monday, November 16, 2020, at 12.00 pm, with the ZOOM method. The guest lecture on medicinal plants is Assoc. Prof. Kosei Yamauchi, a lecturer at Gifu University, Japan. He is a researcher in the field of natural product chemistry, exploring the content of compounds contained in a plant and testing the activity of plant compounds in several biological activities in cells. The guest lecture began with remarks from the dean of the Faculty of Agriculture, Prof. Dr. Ir. Samanhudi, S.P., M.Si, IPM. ASEAN Eng. The guest lecture was guided by moderator Andriyana Setywati, SP., MP., Ph.D. Also present was the Head of the UNS Agrotechnology Study Program, Dr. Ir. Parjanto, M.P as well as lecturers and students of the UNS Agrotechnology Study Program. The Keynote speaker, Assoc. Prof. Kosei Yamauchi conveyed material about the effectiveness of several plants that have activity in increasing melanin content, especially Jajalakan (Helminthostachys zeylanica) that original plants from Indonesia. Jajalakan plant and some of its derivatives have active ingredients in increasing the melanin content in B16 melanoma cells. This guest lecture was enthusiastically responded to by the participants who were marked by many questions related to the effectiveness of several plants against melanin and several derivative compounds that are very active in increasing melanin content.